Oxidative damage mediates the association between polycyclic aromatic hydrocarbon exposure and lung function
نویسندگان
چکیده
منابع مشابه
Chronic polycyclic aromatic hydrocarbon exposure causes DNA damage and genomic instability in lung epithelial cells
Cell exposure to atmospheric polycyclic aromatic hydrocarbons (PAHs) is closely associated with DNA damage and genomic instability. We assessed the mechanisms of chronic and acute PAH exposure-induced genotoxicity in two human lung epithelial cell lines, A549 and NC-H1975. We sampled atmospheric PAHs at the Xixi Campus, Zhejiang University in Hangzhou, China during August (non-haze episode) and...
متن کاملAssociation of Exposure to Polycyclic Aromatic Hydrocarbons with Inflammation, Oxidative DNA Damage and Renal-pulmonary Dysfunctions in Barbecue Makers in Southern Nigeria
Background: Multiple organ dysfunctions have been linked to exposure to polycyclic aromatic hydrocarbons (PAH) and oxidative stress (OS), oxidative DNA damage, and inflammatory response to PAH have been implicated. The biomarkers of OS (malondialdehyde (MDA), total plasma peroxide (TPP), total antioxidant capacity (TAC), glutathione (GSH), nitric oxide (NO), oxidative stress index (OSI)); 8-hy...
متن کاملEnvironmental polycyclic aromatic hydrocarbon (PAH) exposure and DNA damage in Mexican children.
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous pollutants presenting a public health risk, particularly to children, a vulnerable population. PAHs have genotoxic and carcinogenic properties, which depend on their metabolism. Many enzymes involved in PAH metabolism, including CYP1A1, CYP1B1, GSTM and GSTT are polymorphic, which may modulate the activation/deactivation of these compounds....
متن کاملPolycyclic aromatic hydrocarbon selected galaxies
Context. This is the fourth in a series of papers based on the ISOCAM Parallel Survey at 6.7 μm. While the first three papers have been devoted to active galactic nuclei (AGN), here we report on emission-line galaxies without AGN signatures in their optical spectra. Aims. Polycyclic aromatic hydrocarbon (PAH) emission has been found in both starbursts and modestly starforming galaxies, but the ...
متن کاملDetection of polycyclic aromatic hydrocarbon-DNA adducts in human lung.
Molecular dosimetry for polycyclic aromatic hydrocarbon-DNA adducts, genetic predisposition to cancer, and their interrelationships are under study in numerous laboratories. This report describes a modified 32P-postlabeling assay for the detection of polycyclic aromatic hydrocarbon-DNA adducts that uses immunoaffinity chromatography to enhance chemical specificity and quantitative reliability. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Environmental Health
سال: 2020
ISSN: 1476-069X
DOI: 10.1186/s12940-020-00621-x